CompBioLab

Luis Mendoza

Experiencia

Jefe de grupo del CompBioLab.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
De mayo de 2006 a la fecha.

Investigador Asociado en Bioinformática.
Scientific Computing Group.
Serono Pharmaceutical Research Institute, Serono International.
De febrero de 2002 a marzo de 2006.

Investigador Postdoctoral.
Laboratorio del Dr. Wyeth W. Wasserman.
Center for Genomics and Bioinformatics, Karolinska Institute.
De abril de 2000 a enero de 2002.

Estudiante de Doctorado.
Laboratorio de la Dra. Elena Álvarez-Buylla.
Instituto de Ecología, Universidad Nacional Autónoma de México.
Graduado el 23 de Febrero de 2000.

Licenciatura en Investigación Biomédica Básica.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
Graduado el 2 de junio de 1993.

Reconocimientos

Investigador Nacional nivel II.
CONACYT, México.

Premio Thomson Reuters-CINVESTAV por publicar el artículo más citado en una década.
29 de septiembre de 2009.

Mención Honorífica en el título de Doctor en Ciencias.
23 de Febrero de 2000.

Mención Honorífica en el título de Licenciado en Investigación Biomédica Básica.
2 de junio de 1993.

Publicaciones de investigación

Carlos Ramírez and Luis Mendoza (ms).
Phenotypic stability and plasticity in GMP-derived cells as determined by their underlying regulatory network.
Bioinformatics in press.

Nathan Weinstein, Luis Mendoza, Isidoro Gitler, and Jaime Klapp (2017).
A network model to explore the effect of the micro-environment on endothelial cell behavior during angiogenesis.
Frontiers in Physiology in press.

Eugenio Azpeitia, Stalin Munoz, Daniel Gonzalez-Tokman, Mariana Esther Martinez-Sanchez, Nathan Weinstein, Aurelien Naldi, Elena ER Alvarez-Buylla, David A Rosenblueth, and Luis Mendoza (2017).
The combination of the functionalities of feedback circuits is determinant for the number and size of attractors of molecular networks.
Scientific Reports 7: 42023.
PubMed

Jennifer Enciso, Hector Mayani, Luis Mendoza, and Rosana Pelayo (2016).
Modeling the pro-inflammatory tumor microenvironment in acute lymphoblastic leukemia predicts a breakdown of hematopoietic-mesenchymal communication networks.
Frontiers in Physiology 7: 349.
PubMed

Akram Méndez and Luis Mendoza (2016).
A Network Model to Describe the Terminal Differentiation of B Cells.
PLOS Computational Biology 12: e1004696.
PubMed

Luis Mendoza and Akram Méndez (2015).
A dynamical model of the regulatory network controlling lymphopoiesis.
BioSystems 137: 26-33.
PubMed

Osiris Ríos, Sara Frías, Alfredo Rodríguez, Susana Kofman, Horacio Merchant, Leda Torres, and Luis Mendoza (2015).
A Boolean network model of human gonadal sex determination.
Theoretical Biology and Medical Modelling 12: 26.
PubMed

Alfredo Rodríguez, Leda Torres, Ulises Juárez, David Sosa, Eugenio Azpeitia, Benilde García-de Teresa, Edith Cortés, Rocío Ortíz, Ana M. Salazar, Patricia Ostrosky-Wegman, Luis Mendoza, and Sara Frías (2015).
Fanconi Anemia Cells with Unrepaired DNA Damage Activate Components of the Checkpoint Recovery Process.
Theoretical Biology and Medical Modelling 12: 19.
PubMed

Jennifer Enciso, Luis Mendoza, and Rosana Pelayo (2015).
Normal vs Malignant Hematopoiesis: the Complexity of Acute Leukemia Through Systems Biology.
Frontiers in Genetics 6: 290.
PubMed

Mariana Martínez-Sánchez, Luis Mendoza, Carlos Villarreal, and Elena R. Álvarez-Buylla (2015).
A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity.
PLOS Computational Biology 11(6): e1004324.
PubMed

Mariana Díaz-Zaragoza, Ricardo Hernández-Ávila, Tzipe Govezensky, Luis Mendoza, Dulce María Meneses-Ruíz, and Pedro Ostoa-Saloma (2015).
Comparison patterns of 4 T1 antigens recognized by humoral immune response mediated by IgG and IgM antibodies in female and male mice with breast cancer using 2D-immnunoblots.
Immunobiology. 220: 1050-1058.
PubMed

Nathan Weinstein, Elizabeth Ortiz-Gutierrez, Stalin Muñoz, David A. Rosenblueth, Elena R. Álvarez-Buylla, and Luis Mendoza (2015).
A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva.
BMC Bioinformatics 16: 81.
PubMed

Pablo Martínez-Sosa and Luis Mendoza (2013).
The regulatory network that controls the differentiation of T lymphocytes.
BioSystems 113: 96-103.
PubMed

Luis Mendoza (2013).
A virtual culture of CD4+ T lymphocytes.
Bulletin of Mathematical Biology 75: 1012-1029.
PubMed

Nathan Weinstein and Luis Mendoza (2013).
A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans.
Frontiers in Genetics 4: 112.
PubMed

Eugenio Azpeitia, Nathan Weinstein, Mariana Benítez, Luis Mendoza and Elena R. Alvarez-Buylla (2013).
Finding missing interactions of the Arabidopsis thaliana root stem cell niche gene regulatory network.
Frontiers in Plant Science 4: 110.
PubMed

Nathan Weinstein and Luis Mendoza (2012).
Building qualitative models of plant regulatory networks with SQUAD.
Frontiers in Plant Science 3: 72.
PubMed

Alfredo Rodríguez, David Sosa, Leda Torres, Bertha Molina, Sara Frías and Luis Mendoza (2012).
A Boolean network model of the FA/BRCA pathway.
Bioinformatics 28: 858-866.
PubMed

María Fernanda Higareda, Otto Geiger, Luis Mendoza and Rafael A. Méndez-Sánchez (2012).
Evidence of codon usage in the nearest neighbor spacing distribution of bases in bacterial genomes.
Physica A 391: 1255-1269.
DOI

Luis Mendoza and Fátima Pardo (2010).
A robust model to describe the differentiation of T-helper cells.
Theory in Biosciences 129: 283-293.
PubMed

Yara-Elena Sánchez-Corrales, Elena R. Álvarez-Buylla and Luis Mendoza (2010).
The Arabidopsis thaliana flower organ specification gene regulatory network determines a robust differentiation process.
Journal of Theoretical Biology 264: 971-983.
PubMed

Abhishek Garg, Alessandro Di Cara, Ioannis Xenarios, Luis Mendoza and Giovanni De Micheli (2008).
Synchronous vs. asynchronous modelling of gene regulatory networks.
Bioinformatics 24: 1917-1925.
PubMed

Alessandro Di Cara, Abhishek Garg, Giovanni De Micheli, Ioannis Xenarios and Luis Mendoza (2007).
Dynamic simulation of regulatory networks using SQUAD.
BMC Bioinformatics 8: 462.
PubMed

Abhishek Garg, Luis Mendoza, Ioannis Xenarios and Giovanni De Micheli (2007).
Modeling of Multiple Valued Gene Regulatory Networks.
Conf. Proc. IEEE Eng. Med. Biol. Soc. 2007 1: 1398-1404.
PubMed

Abhishek Garg, Ioannis Xenarios, Luis Mendoza and Giovanni DeMicheli (2007).
An efficient method for dynamic analysis of gene regulatory networks and in silico gene perturbation experiments.
RECOMB 2007, Lecture Notes in Computer Science 4453: 62-76.
DOI

Luis Mendoza (2006).
A network model for the control of the differentiation process in Th cells.
BioSystems 84: 101-114
PubMed

Luis Mendoza and Ioannis Xenarios (2006).
A method for the generation of standardized qualitative dynamical systems of regulatory networks.
Theoretical Biology and Medical Modelling 3:13
PubMed

Elisabeth Remy, Paul Ruet, Luis Mendoza, Denis Thieffry and Claudine Chaouiya (2006).
From logical regulatory graphs to standard petri nets: Dynamical roles and functionality of feedback circuits.
Transactions on Computational Systems Biology VII, Lecture Notes in Computer Science 4230: 56-72
DOI

Boris Lenhard, Albin Sandelin, Luis Mendoza, Pär Engström, Niclas Jareborg and Wyeth W. Wasserman (2003).
Identification of conserved regulatory elements by comparative genome analysis.
Journal of Biology 2:13
PubMed

Luis Mendoza and Elena R. Alvarez-Buylla (2000).
Genetic regulation of root hair development in Arabidopsis thaliana: a network model.
Journal of Theoretical Biology 204:311
PubMed

Luis Mendoza, Denis Thieffry and Elena R. Alvarez-Buylla (1999).
Genetic control of flower morphogenesis in Arabidopsis thaliana: a logical analysis.
Bioinformatics 15:593
PubMed

Luis Mendoza and Elena R. Alvarez-Buylla (1998).
Dynamics of the genetic regulatory network for flowering in Arabidopsis thaliana.
Journal of Theoretical Biology 193: 307-319.
PubMed

Luis Mendoza, Mariana Mondragón and Jaime Lagúnez-Otero (1998).
Interactions of the 530 ribosomal site with subregions of mRNA.
Biosystems 46:293
PubMed

Luis Mendoza and Jaime Lagúnez-Otero (1996).
The ribosome as an exon detector.
Biosystems 38:45
PubMed

Libros y capítulos de libros

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2015).
Biología Conceptual.
1a Edición. Trillas, 2015. ISBN: 9786071723178.
info

Enrique Mendoza Sierra, Luis Antonio Mendoza Sierra, Margarita Dalila Mendoza Gálvez, Iliana Ahtenea Mendoza Gálvez, Enrique Mendoza Gálvez y Margarita Gálvez Barón (2015).
La Biblia del Médico General: Diagnóstico y tratamiento de las cien enfermedades más frecuentes.
Amazon Digital Services, Inc. ASIN: B00UMIS2S2.
info

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2014).
Biología II.
1a Reimpresión. Trillas, 2009. ISBN: 978-607-17-0078-0.
info

Luis Mendoza (2014).
Definiciones: Qualitative differential equations, Piecewise-linear models, and Standardized Qualitative Dynamical Systems.
En: Concise Encyclopaedia of Bioinformatics and Computational Biology, 2nd Edition. John M. Hancock and Marketa J. Zvelebil (Editors).
Wiley-Blackwell. ISBN: 978-0-470-97871-9.

Pascal Kahlem, Alessandro DiCara, Maxime Durot, John M. Hancock, Edda Klipp, Vincent Schächter, Eran Segal, Ioannis Xenarios, Ewan Birney, and Luis Mendoza (2011).
Strengths and Weaknesses of Selected Modeling Methods used in Systems Biology.
En: Systems and Computational Biology - Bioinformatics and Computational Modeling. Dr. Ning-Sun Yang (Ed.). InTech. 978-953-307-875-5.

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2011).
Biología I.
1a Edición. Trillas, 2011. ISBN: 978-607-17-0640-9.
info

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2009).
Biología II.
1a Edición. Trillas, 2009. ISBN: 978-607-17-0078-0.
info

Elizabeth Santiago-Cortés and Luis Mendoza (2008).
Chapter XXXI: Discrete State Networks as a Suitable Approach for the Analysis of Genetic Regulation.
En: Handbook of Research on Systems Biology Applications in Medicine. Andriani Daskalaki (Ed.). Medical Information Science Reference.

Francisco Vergara-Silva, Caroline Burgeff d`Hondt, Liz Yazmín Izquierdo, Alicia Gamboa de Buen, Rosalinda Tapia-López, Luis Mendoza,and María Elena Alvarez-Buylla Roces (2003).
Genes homeóticos y mecanismos moleculares de diferenciación.
En: Biología Celular y Molecular. Luis Felipe Jiménez and Horacio Merchant (Eds). Prentice Hall, México.

Gonzalo Martínez de la Escalera, Luis Mendoza, Alejandra Ochoa and Dirk Hol (1993).
Nuevas tendencias en el análisis experimental de la comunicación neuroendócrina: las células GT1.
En: Comunicación neuroendócrina: bases celulares y moleculares.
Clapp y Martínez de la Escalera (Eds.). SMCF, CONACYT, SEP. México.

Otras publicaciones

Luis Mendoza (2009).
Modelado de multitudes.
Gaceta Biomédicas 14(1): 10-11.

Fátima Pardo y Luis Mendoza (2008).
Los sistemas dinámicos discretos.
Gaceta Biomédicas 13(2): 12-14.

Luis Mendoza (2007).
Modelado de linfocitos T cooperadores.
Gaceta Biomédicas 12(3): 6.

Luis Mendoza (2006).
A network model for the differentiation of T-helper lymphocytes.
Foro-Red-Mat 13: 3.

Luis Mendoza, Francisco Caviedes and Nydia Lara (1998)
The metaphysics behind studies of neural motor control.
En: Research-in-progress, Volume V. George E. Lasker (Ed.). The International Institute for Advanced Studies in Systems Research and Cybernetics. 1998. p41-45.

Elena Alvarez-Buylla, Luis Mendoza and Francisco Vergara (1996).
Orden y caos en la biología: la autoorganización como fuente de complejidad en los seres vivos.
Universidad de México 540:58